Anslational-medicine/content/12/1/Page 7 ofAuthor details 1 Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Investigation Council (CNR) – Traversa La Crucca 3, Baldinca Li Punti, 07100 Sassari, Italy. 2Dipartimento di Scienze Chirurgiche, Microchirurgiche e Mediche, University of Sassari, Sassari, Italy. 3Department of Dermatology, University of Firenze, Firenze, Italy. 4Skin Cancer Unit, Istituto Scientifico Romagnolo per Studio e Cura dei Tumori, Meldola, Italy. 5Istituto Nazionale Tumori Fondazione Pascale, Napoli, Italy. 6Department of Pathology, University of Firenze, Firenze, Italy. 7Unit of Plastic Surgery, University of Salerno, Salerno, Italy. Received: two April 2014 Accepted: two May perhaps 2014 Published: eight May well 2014 References 1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127:2893?917. two. Dummer R, Hauschild A, Guggenheim M, Keilholz U, Pentheroudakis G: ESMO Recommendations Operating Group: Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, remedy and follow-up. Ann Oncol 2012, 23(Suppl 7):vii86 ii91. 3. Gandini S, Sera F, Cattaruzza MS, Pasquini P, Zanetti R, Masini C, Boyle P, Melchi CF: Meta-analysis of threat factors for cutaneous melanoma: III. Family history, actinic harm and phenotypic components. Eur J Cancer 2005, 41:2040?059. four. Whiteman DC, Stickley M, Watt P, Hughes MC, Davis MB, Green AC: Anatomic website, sun exposure, and danger of cutaneous melanoma. J Clin Oncol 2006, 24:3172?177. 5. Chaudru V, Chompret A, Bressac-de Paillerets B, Spatz A, Avril MF, Demenais F: Influence of genes, nevi, and sun sensitivity on melanoma risk inside a loved ones sample unselected by loved ones history and in melanoma-prone households.1209487-56-8 Purity J Natl Cancer Inst 2004, 96:785?95. six. Ferrone CR, Ben Porat L, Panageas KS, Berwick M, Halpern AC, Patel A, Coit DG: Clinicopathological capabilities of and danger aspects for various principal melanomas. JAMA 2005, 294:1647?654. 7. Murali R, Goumas C, Kricker A, From L, Busam KJ, Begg CB, Dwyer T, Gruber SB, Kanetsky PA, Orlow I, Rosso S, Thomas NE, Berwick M, Scolyer RA, Armstrong BK, GEM Study Group: Clinicopathologic options of incident and subsequent tumors in sufferers with multiple principal cutaneous melanomas. Ann Surg Oncol 2012, 19:1024?033. eight. Bower MR, Scoggins CR, Martin RC 2nd, Mays MP, Edwards MJ, Reintgen DS, Ross MI, Urist MM, Noyes RD, Sussman JJ, Hagendoorn LJ, Stromberg AJ, McMasters K: Second major melanomas: incidence and outcome.1783407-55-5 web Am Surg 2010, 76:675?81.PMID:24624203 9. De Giorgi V, Rossari S, Papi F, Gori A, Alfaioli B, Grazzini M, Crocetti E, Verdelli A, Foo CW, Lotti T: Multiple key melanoma: the influence of atypical naevi and adhere to up. Br J Dermatol 2010, 163:1319?322. 10. Hwa C, Price LS, Belitskaya-Levy I, Ma MW, Shapiro RL, Berman RS, Kamino H, Darvishian F, Osman I, Stein JA: Single versus several principal melanomas: old concerns and new answers. Cancer 2012, 118:4184?192. 11. Moscarella E, Rabinovitz H, Puig S, Zalaudek I, Oliviero MC, Brown L, Alarcon I, Malvehy J, Longo C, Formisano D, Carrera C, Badenas C, Piana S, Albertini G, Pellacani G, Argenziano G: Various primary melanomas: do they appear exactly the same? Br J Dermatol 2013, 168:1267?272. 12. Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sober AJ, Sondak VK: Final ve.